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特別演講 - 何秉智 博士
何秉智 博士
Ping-ChihHo, Ph.D.
Assistant Professor
Department of Fundamental Oncology, University of Lausanne

演講題目:What you eat makes you strong and vulnerable: metabolic interruption of intratumor Tregs for cancer treatment
時間:108年 01月 14日 星期一 17:00 - 19:00
地點:長庚大學 第二醫學大樓B1 會議廳三

Scientific abstract

The aberrant accumulation of regulatory T cells (Tregs) in the tumor microenvironment impairs anti-tumor immunity and represents a major hurdle for effective cancer immunotherapy. Although targeting Tregs unleash host anti-tumor immunity and improve therapeutic effects of immunotherapies, autoimmune responses minimize the therapeutic potential of Treg targeting approaches. Here, we find intratumoral Tregs display unique metabolic preference to support their survival and suppressive activity in the tumor microenvironment. We further demonstrate intervening this metabolic pathway could selectively wane down intratumoral Tregs and unleash anti-tumor responses.
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