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長庚大學 臨床醫學研究所

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特別演講 - 史涵宇 博士

史涵宇 博士
Han-Yu Shih, Ph. D.
Investigator
National Institutes of Health, USA

Seminar
Regulomes in lymphocyte differentiation and activation
時間:108年 05月 20日 星期一 13:00 – 15:00
地點:長庚大學 第二醫學大樓會議廳B1 第二會議廳

abstract
Precise immune responses are critical for immune-related diseases and therapy. However, cell type- and pathway- specific therapeutic targets remain limited because we do not fully understand the mechanisms of immune gene regulation. Using genomic approaches, we identified regulatory elements that underlie lymphocyte functionality during development and activation. We also dissected distinct enhancer types based on chromatin accessibility and binding of an enhancer marker, p300. Our transcriptomic and epigenomic analysis revealed that activation of innate lymphoid cells provoke distinct cascades of epigenetic changes at individual enhancers, altogether, facilitating prompt immune response.
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