2023.04.14
Congratulations to gicm doctoral student Jhan-Jie Peng, who during his study period collaborated with Professor Ping-Chih Ho's laboratory at the University of Lausanne in Switzerland on research into autoimmune diseases involving autoantibodies. He recently published a comprehensive review article on Chimeric Antigen Receptor T-cell (CAR-T) Therapy in the international journal, Science Immunology.
CAR-T cell therapy is a burgeoning immunotherapy method in recent years, which has been proven to have significant effects on blood cancers such as B-cell lymphoma and acute lymphoblastic leukemia. The prevalent method involves collecting T-cells from the patient, then redesigning them into CAR-T cells that have the ability to target specific tumor antigens. With the emergence of CAR-T cell therapy, ongoing research aims to improve the manufacturing and management techniques and processes of CAR-T cell therapy and extend this form of cell therapy to many other types of cancer.
This article primarily reviews successful cases of cancer treatment in the past and discusses the challenges currently faced by CAR-T cell therapy. It also explores the possibility of enhancing the effectiveness of CAR-T cell therapy for specific cancer cells by adjusting their metabolism via the tumor microenvironment. We believe that with the joint research efforts of numerous scientists, new treatment options can be developed for more cancer patients and those with special diseases.