洪千惠 副教授
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洪千惠 (Chein-Hui Hung) |
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職稱：副教授 |
研究室：嘉義長庚醫院第一共同研究室 |
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最高學歷：Ph.D. |
學校/國家：陽明大學 / 台灣 |
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分機號碼：(405) 2098 |
電子郵件帳號：hungc01@mail.cgu.edu.tw |
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研究室現有：專任研究助理 3 人 |
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研究方向及特色： Our lab focuses on understanding the mechanism of virion maturation of the Epstein-Barr virus (EBV) and its associated pathogenesis. EBVs belong to large double-stranded DNA tumor viruses and infect 95% of the adult human population worldwide. EBV infection during adolescence causes infectious mononucleosis (IM). In addition, EBV is highly associated with various lymphoid and epithelial malignancies, e.g., Burkitt’s lymphoma, Hodgkin’s lymphoma, various T-/NK-/B- cell non-Hodgkin lymphoma, nasopharyngeal carcinoma (NPC), and gastric carcinoma.
The mature virion of EBV contains 6 capsid proteins, 10 viral glycoproteins, at least 17 viral-encoded tegument proteins. The formation of mature virion involves complex interactions among the capsid, tegument and glycoproteins, and is temporal-spatially and sequentially regulated. However, it is mostly unknown in the Epstein-Barr virus due to the lack of a permissive cell culture system for lytic infection. Our study revealed that BGLF2 and BBLF1 are critical to virion maturation. BGLF2 regulates virion maturation sequentially, which interacts with capsids and functions as an instructor, directing the nucleocapsid to TGN for final envelopment through the interaction with TGN-localized BBLF1 (Figure)
Our study currently revealed BGLF2 associated with at least 16 viral tegument or capsid proteins from the proteomic study. The ongoing study is focusing on these interactions with BLGF2 and the contribution to EBV virion maturation. BGLF2 influences cellular signaling pathways, such as activation of the MAPK pathway, cell cycle arrest at the G1 phase, and inhibition of anti-viral interferon signaling, to promote EBV infection. In addition, our proteomic study revealed BGLF2 associates with cellular proteins involved in the translation pathway, DNA repair, anti-viral response, trafficking, and proteolysis. The importance of BGLF2 interactome in EBV maturation, EBV lytic cycle regulation, and EBV pathogenesis are currently investigated. Our study will provide a better understanding of EBV pathogenesis and therapeutic targets for EBV associated diseases. |
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